Each platelet remains alive for only about 10 days, so the body keeps on making new platelets in the bone marrow. When bone marrow does not produce enough new platelets or breaks down rapidly, thrombocytopenia can occur. The accumulation or abnormal distribution of platelets can lead to diseases related to the spleen. It can be hereditary and also due to certain medicines or many other conditions. Platelets count can be low due to one or various reasons.